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Träfflista för sökning "WFRF:(Li XZ) ;pers:(Jin H.);mspu:(article)"

Search: WFRF:(Li XZ) > Jin H. > Journal article

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  • Yao, JT, et al. (author)
  • Early modulation of macrophage ROS-PPARγ-NF-κB signalling by sonodynamic therapy attenuates neointimal hyperplasia in rabbits
  • 2020
  • In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1, s. 11638-
  • Journal article (peer-reviewed)abstract
    • Disruption of re-endothelialization and haemodynamic balance remains a critical side effect of drug-eluting stents (DES) for preventing intimal hyperplasia. Previously, we found that 5-aminolevulinic acid-mediated sonodynamic therapy (ALA-SDT) suppressed macrophage-mediated inflammation in atherosclerotic plaques. However, the effects on intimal hyperplasia and re-endothelialization remain unknown. In this study, 56 rabbits were randomly assigned to control, ultrasound, ALA and ALA-SDT groups, and each group was divided into two subgroups (n = 7) on day 3 after right femoral artery balloon denudation combined with a hypercholesterolemic diet. Histopathological analysis revealed that ALA-SDT enhanced macrophage apoptosis and ameliorated inflammation from day 1. ALA-SDT inhibited neointima formation without affecting re-endothelialization, increased blood perfusion, decreased the content of macrophages, proliferating smooth muscle cells (SMCs) and collagen but increased elastin by day 28. In vitro, ALA-SDT induced macrophage apoptosis and reduced TNF-α, IL-6 and IL-1β via the ROS-PPARγ-NF-κB signalling pathway, which indirectly inhibited human umbilical artery smooth muscle cell (HUASMC) proliferation, migration and IL-6 production. ALA-SDT effectively inhibits intimal hyperplasia without affecting re-endothelialization. Hence, its clinical application combined with bare-metal stent (BMS) implantation presents a potential strategy to decrease bleeding risk caused by prolonged dual-antiplatelet regimen after DES deployment.
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  • Result 1-4 of 4
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journal article  (4)Undo refine
Type of content
peer-reviewed (4)
Author/Editor
Jin, H. (4)Undo refine
Tian, Y. (4)
Cao, ZY (4)
Li, BC (4)
Zhao, XZ (4)
Zhang, ZG (4)
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Guo, SY (3)
Yao, JT (3)
Sun, X. (2)
Cao, Y (2)
Wang, L (2)
Tian, Z. (2)
Zhang, HY (2)
Tan, FC (2)
Liu, MY (2)
Shen, ZQ (2)
Jiang, YX (2)
Sheng, SQ (2)
Lu, MQ (2)
Diabakte, K (2)
Cao, XR (2)
Chen, X. (1)
Li, Y. (1)
Liu, B. (1)
Tian, F. (1)
Wang, H. (1)
Li, X. (1)
Zhang, Y. (1)
Wang, Y. (1)
Huang, X. (1)
Huang, Z. (1)
Li, K. (1)
Wang, W. (1)
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Zhao, H (1)
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Li, JY (1)
Liu, YR (1)
Gao, WW (1)
Pourteymour, S (1)
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University
Karolinska Institutet (4)
Language
English (4)

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